Drug hypersensitivity: Pharmacogenetics and clinical syndromes
نویسندگان
چکیده
منابع مشابه
Pharmacogenetics of drug hypersensitivity.
Drug hypersensitivity reactions and severe cutaneous adverse drug reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, are examples of serious adverse drug reactions mediated through a combination of metabolic and immunological mechanisms that could traditionally not have been predicted based on the pharmacological characteristics of the drug alone. The discovery of new a...
متن کاملHLA and pharmacogenetics of drug hypersensitivity.
Immunologically mediated drug reactions have been traditionally classified as unpredictable based on the fact that they cannot be predicted strictly on the pharmacological action of the drug. Such adverse drug reactions are associated with considerable morbidity and include severe cutaneous adverse reactions such as Stevens-Johnson syndrome/toxic epidermal necrolysis and the drug hypersensitivi...
متن کاملPharmacogenetics and Predictive Testing of Drug Hypersensitivity Reactions
Adverse drug reactions adverse drug reaction (ADR) occur in approximately 17% of patients. Avoiding ADR is thus mandatory from both an ethical and an economic point of view. Whereas, pharmacogenetics changes of the pharmacokinetics may contribute to the explanation of some type A reactions, strong relationships of genetic markers has also been shown for drug hypersensitivity belonging to type B...
متن کاملPharmacogenetics, drug-metabolizing enzymes, and clinical practice.
The application of pharmacogenetics holds great promise for individualized therapy. However, it has little clinical reality at present, despite many claims. The main problem is that the evidence base supporting genetic testing before therapy is weak. The pharmacology of the drugs subject to inherited variability in metabolism is often complex. Few have simple or single pathways of elimination. ...
متن کاملDrug hypersensitivity reactions: pathomechanism and clinical symptoms.
Small molecules, used as drugs, can induce immune reactions by binding covalently as haptens to a carrier protein, which is thereby modified and immunogenic. In addition, drugs bind to proteins via hydrogen bonds, electrostatic force, and van der Waals forces, and may directly interact with immune receptors such as T cell receptors or major histocompatibility complex molecules (pharmacologic in...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2011
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2010.11.046